Abstract Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in
several preclinical models. The aim of the present study was to evaluate the effect of …

Angiogenesis plays a crucial role in tumor development and growth. The present
investigation was undertaken to test the potential involvement of the cyclooxygenase-2 …

The purpose of the present study was to elucidate the effects of cyclooxygenase 2 (COX‑2)
on the expression of vascular endothelial growth factor (VEGF) and prostaglandin E2 …

Abstract Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has recently been
shown to affect the development of different types of cancer. The present study utilized a …

In some cancers cyclooxygenase (COX) inhibition appears to be anti-mitogenic and anti-
angiogenic, but the actions of COX-derived prostaglandins in pancreatic cancer (PaCa) are …

Previous studies suggest that antagonists of cyclooxygenases 1 and 2 (COX-1,-2) inhibit
angiogenesis in tumor xenografts, but the molecular mechanisms involved remain unclear …

Purpose: COX-2 is expressed highly in pancreatic cancer and implicated in tumor
progression. COX-2 inhibition can reduce tumor growth and augment therapy. The precise …

Although gastric cancer with cyclooxygenase (COX)-2 overexpression is associated with
poor prognosis, the mechanistic pathway remains unknown. We examined the associations …

Abstract Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) have been
reported to be significantly related to carcinogenesis or progression of various cancers …

Angiogenesis plays a key role in the development of malignant tumors. To clarify the roles of
cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated …