Bio-psycho-social factors' associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

M Korbmacher, TP Gurholt, AMG de Lange… - Frontiers in …, 2023 - frontiersin.org
Brain age refers to age predicted by brain features. Brain age has previously been
associated with various health and disease outcomes and suggested as a potential …

[HTML][HTML] Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors

JH Cole - Neurobiology of aging, 2020 - Elsevier
The brain-age paradigm is proving increasingly useful for exploring aging-related disease
and can predict important future health outcomes. Most brain-age research uses structural …

Linking brain age gap to mental and physical health in the Berlin aging study II

P Jawinski, S Markett, J Drewelies, S Düzel… - Frontiers in Aging …, 2022 - frontiersin.org
From a biological perspective, humans differ in the speed they age, and this may manifest in
both mental and physical health disparities. The discrepancy between an individual's …

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants

K Ning, L Zhao, W Matloff, F Sun, AW Toga - Scientific reports, 2020 - nature.com
Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain
anatomical characteristics. While associations between individual human brain regions and …

Dissecting unique and common variance across body and brain health indicators using age prediction

D Beck, AMG de Lange, TP Gurholt… - Human Brain …, 2024 - Wiley Online Library
Ageing is a heterogeneous multisystem process involving different rates of decline in
physiological integrity across biological systems. The current study dissects the unique and …

Individual variations in 'brain age'relate to early-life factors more than to longitudinal brain change

D Vidal-Pineiro, Y Wang, SK Krogsrud, IK Amlien… - elife, 2021 - elifesciences.org
Brain age is a widely used index for quantifying individuals' brain health as deviation from a
normative brain aging trajectory. Higher-than-expected brain age is thought partially to …

Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations

SM Smith, LT Elliott, F Alfaro-Almagro, P McCarthy… - elife, 2020 - elifesciences.org
Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …

[HTML][HTML] Age differentiation within gray matter, white matter, and between memory and white matter in an adult life span cohort

SMM de Mooij, RNA Henson, LJ Waldorp… - Journal of …, 2018 - Soc Neuroscience
It is well established that brain structures and cognitive functions change across the life
span. A long-standing hypothesis called “age differentiation” additionally posits that the …

An exploratory causal analysis of the relationships between the brain age gap and cardiovascular risk factors

P Mouches, M Wilms, JJ Bannister, A Aulakh… - Frontiers in Aging …, 2022 - frontiersin.org
The brain age gap (BAG) has been shown to capture accelerated brain aging patterns and
might serve as a biomarker for several neurological diseases. Moreover, it was also shown …

[HTML][HTML] The Aging Brain Cohort (ABC) repository: The University of South Carolina's multimodal lifespan database for studying the relationship between the brain …

RD Newman-Norlund, SE Newman-Norlund… - Neuroimage …, 2021 - Elsevier
This paper describes the public repository that houses multimodal data collected as part of
Aging Brain Cohort study being conducted at the University of South Carolina (ABC …