Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

Demand for oral alternatives to parenteral delivery has led to renewed interest in excipient-
like intestinal permeation enhancers that improve oral drug bioavailability. Oral delivery of …

The use of chemical permeation enhancers (PEs) is the most widely tested approach to
improve oral absorption of low permeability active agents, as represented by peptides …

Oral delivery of macromolecular drugs, particularly peptides and proteins, is the focus of
many academic and industrial laboratories. Armed with an increased understanding of the …

It is not uncommon for peptides and structurally-similar non-peptides to have poor intestinal
permeability and low oral bioavailability. One possible way to solve a permeability problem …

ABSTRACT Introduction Intestinal permeation enhancers (PEs) are substances that
transiently alter the intestinal epithelial barrier to facilitate permeation of macromolecules …

A wide variety of peptide drugs are now produced on a commercial scale as a result of
advances in the biotechnology field. Most of these therapeutic peptides are still administered …

The clinical development of orally active peptide drugs has been restricted by their
unfavorable physicochemical characteristics, which limit their membrane permeation, and …

Intestinal permeation enhancers (PEs) are key components in∼ 12 oral peptide
formulations in clinical trials for a range of molecules, primarily insulin and glucagon-like …

Introduction: Pharmaceutical research and development is increasingly focussed on
biopharmaceuticals including peptide and protein drugs. Despite their growing importance …