Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …

Over the past years, extracellular matrix (ECM) obtained from whole organ decellularization
has been investigated as a platform for organ engineering. The ECM is composed of fibrous …

Background: In 2012, about 16,487 people received kidney transplants in the USA whereas
95,022 candidates were on the waiting list at the end of the year. Moreover, more than 2,600 …

In the United States, more than 2600 kidneys are discarded annually, from the total number
of kidneys procured for transplant. We hypothesized that this organ pool may be used as a …

Kidney transplantation is the only potentially curative treatment for patient facing end-stage
renal disease, and it is now routinely used. Its use is mainly limited by the supply of …

Native extracellular matrix (ECM) that is secreted and maintained by resident cells is of great
interest for cell culture and cell delivery. We hypothesized that specialized bioengineered …

Recent research has shown that fully developed organs can be decellularized, resulting in a
complex scaffold and extracellular matrix (ECM) network capable of being populated with …

It has not been considered that nephrons regenerate in adult mammals. We present that an
organ-derived extracellular matrix in situ induces nephron regeneration in a preclinical …

Background: In the attempt to develop a clini-cally relevant platform for kidney
bioengineering, we have previously demonstrated that human renal extracellular matrix …

Background: Chronic kidney disease (CKD) is a global public health issue with an estimated
prevalence of 8-16% worldwide. End-stage renal disease eventually develops every year in …