Feature Selection and mRNA-miRNA bipartite Network Analysis for Biomarker Development and Drug Repurposing in Colon Cancer

PG Zavarzadeh, Z Abedi, A Abbasi, H MotieGhader… - 2024 - researchsquare.com
Background: Colon cancer (CC) is the second cause of mortality among other non-skin
cancers. Despite the progression in screening and diagnostic strategies, further information …

mRNA–miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation

H Motieghader, M Kouhsar, A Najafi, B Sadeghi… - Molecular …, 2017 - pubs.rsc.org
Biomarker detection is one of the most important and challenging problems in cancer
studies. Recently, non-coding RNA based biomarkers such as miRNA expression levels …

Identifying miRNA and gene modules of colon cancer associated with pathological stage by weighted gene co-expression network analysis

X Zhou, X Huang, S Liang, S Tang, S Wu… - OncoTargets and …, 2018 - Taylor & Francis
Introduction Colorectal cancer (CRC) is the fourth most common cause of cancer-related
mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC …

[HTML][HTML] Identification of potential gene and microRNA biomarkers for colon cancer by an integrated bioinformatical approach

Q Ma, J Song, Z Chen, L Li, B Wang… - Translational Cancer …, 2018 - tcr.amegroups.org
Background: A unique resource for genomic studies is the NCI-60 cancer cell line panel,
which provides various publicly available datasets, including gene and microRNA (miRNA) …

Identification and Validation of Key miRNAs for Colon Cancer Based on miRNA-Gene Integration Analysis

Y Ji, J Gu, H Zhang, H Xu - International Journal of General …, 2023 - Taylor & Francis
Background MicroRNAs (miRNAs) plays an essential role in the pathogenesis of colon
cancer. This study aims to identify and verify key miRNAs that may serve as potential …

Drug repurposing analysis for colorectal cancer through network medicine framework: Novel candidate drugs and small molecules

U Unal, E Gov - Cancer Investigation, 2023 - Taylor & Francis
This study aimed to reveal the drug-repurposing candidates for colorectal cancer (CRC) via
drug-repurposing methods and network biology approaches. A novel, differentially co …

[HTML][HTML] Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer

WS Chen, TW Chen, TH Yang, LY Hu, HW Pan… - BMC genomics, 2013 - Springer
Background MicroRNAs (miRNAs) are short noncoding RNAs (approximately 22
nucleotides in length) that play important roles in colorectal cancer (CRC) progression …

[HTML][HTML] Identification and interaction analysis of molecular markers in colorectal cancer by integrated bioinformatics analysis

B Han, D Feng, X Yu, Y Zhang, Y Liu… - Medical science monitor …, 2018 - ncbi.nlm.nih.gov
Results A total of 264 DEGs and 8 DEMs were obtained. GO analysis revealed that the
DEGs were enriched in terms of cell structure, digestion, receptor binding, and extracellular …

[HTML][HTML] Revealing potential immunotherapy targets through analysis of a ceRNA network in human colon adenocarcinoma

C Li, Z Zhu, Q Hou, B Wang, L Zou, L Liu… - Translational Cancer …, 2021 - ncbi.nlm.nih.gov
Background Microsatellite instability-high (MSI-H) is a special type of human colon
adenocarcinoma (COAD) that responds well to immunotherapy. MicroRNAs (miRNAs) and …

Integrative analysis of molecular genetic targets and pathways in colorectal cancer through screening large-scale microarray data

E Onur, T Denkçeken - International Journal of Data Mining …, 2021 - inderscienceonline.com
Our aim was to make comprehensive analyses of mRNAs and miRNAs in early diagnosis of
Colorectal Cancer (CRC) via Principal Component Analysis (PCA)-based Unsupervised …