Background Colorectal cancer (CRC) is one of the most common and comprehensively
studied malignancies. Hypoxic conditions during formation of CRC may support the …

Previous studies have indicated that prolyl hydroxylases (PHDs) function as tumor
suppressors in human colorectal cancer (CRC), but their clinical and prognostic significance …

BACKGROUND & AIMS: Prolyl hydroxylase (PHD) hydroxylates hypoxia inducible factor
(HIF) α, leading to HIFα degradation. The PHD family comprises PHD1, PHD2, and PHD3 …

Hypoxia-induced factors (HIFs) play a central role in the adaptive mechanisms of cancer
cells to survive under conditions of hypoxia. HIFs are regulated by prolyl hydroxylases …

Background The prolyl-hydroxylase domain family of enzymes (PHD1-3) plays an important
role in the cellular response to hypoxia by negatively regulating HIF-α proteins. Disruption of …

Hypoxic conditions during the formation of colorectal cancer may support the development
of more aggressive tumors. Hypoxia-inducible factor (HIF) is a heterodimeric complex …

Huang KT, Mikeska T, Dobrovic A & Fox SB (2010) Histopathology 57, 451–460 DNA
methylation analysis of the HIF‐1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 …

PURPOSE: Hypoxia in tumors is associated with poor prognosis and resistance to treatment.
The outcome of hypoxia is largely regulated by the hypoxia-inducible factors (HIF-1alpha …

Hypoxia is a common feature of solid tumors. Prolyl hydroxylase enzymes (PHD1–3) are
molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions …

Purpose We previously found that hypoxia-inducible factor (HIF) prolyl hydroxylase-3
(PHD3) was frequently overexpressed in renal cell carcinomas (RCCs), unlike in normal …