Energy homeostasis is accomplished through a highly integrated and redundant
neurohumoral system. Recently, novel molecular mediators and regulatory pathways for …

Recently novel molecular mediators and regulatory pathways for feeding and body weight
regulation have been identified in the brain and the periphery. Mice lacking or …

Over the last decade, understanding of the circuits and molecules involved in the regulation
of energy balance has expanded dramatically. A complex system has evolved which allows …

Abstract Knowledge of the genetic and regulatory factors that influence energy homeostasis
is advancing rapidly. There is increased understanding of the molecular signals that reach …

Abstract Changes in physical activities and feeding habits have transformed the historically
rare disease of obesity into a modern metabolic pandemic. Obesity occurs when energy …

The animal models that have been used for the study of obesity have been either of
spontaneous origin or the result of experimental manipulation of the environment or the …

This article reviews novel developments in the behavioral and pharmacologic treatment of
obesity and explores the potential contribution of genomics research to weight control. A …

For decades, increasingly sophisticated methods have been designed to address the
problem of the involvement of the brain in the physiology of energy homeostasis and the …

Obesity could well become the most common health problem of the 21 st century. There are
more opportunities to consume large quantities of food: big portions of tasty, varied food, at …

Neuronal control of body energy homeostasis is the key mechanism by which animals and
humans regulate their long-term energy balance. Various hypothalamic neuronal circuits …