Currently, most of the approved protein and peptide-based medicines are delivered via
conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent …

Purpose The aim of this study was to investigate the potential of using a spray-dryer
equipped with a 3-fluid nozzle to microencapsulate protein drugs into polymeric …

Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Poly (lactic-co-glycolic acid)(PLGA) is the most widely used biomaterial for
microencapsulation and prolonged delivery of therapeutic drugs, proteins and antigens …

Poly (d, l-lactic-co-glycolic acid)(PLGA) microparticles encapsulating therapeutic proteins
were prepared under a water-free formulation condition. Bovine serum albumin (BSA) and …

The aim was to study the effect of the type of polymer solvent on characteristics of
microspheres produced by spray drying. The water-soluble model protein, bovine serum …

During the last decades, many of the poorly controlled diseases were treated using newly
developed peptide and proteins. Although the majority of such therapeutic moieties have …

Purpose The purpose of this study was to modulate the release profiles of the model protein
drug from spray dried poly (DL-lactic-co-glycolic acid)(PLGA) microparticles by incorporating …

The objective of this study was to evaluate the effect of polymer and microsphere blending in
achieving both a sufficient initial release and a desired continuous release of a peptide from …

For ternary solid dispersions, it is indispensable to characterize their structure, phase
behavior, and the spatial distribution of the dispersed drug as this might influence the …