Methadone has several unique characteristics that make it an attractive option for pain relief
in serious illness, but the safety of methadone has been called into question after reports of …

Once used only as third-line therapy for chronic pain management, methadone is now being
used as first-and second-line therapy in palliative care. The risks and stigma associated with …

There are several strong opioids available for the treatment of cancer pain. However, one
has remained in a pharmacotherapeutic abyss until recently. While opioids possess the …

Objective. To identify frequency and utilization patterns of methadone by hospice patients in
the home-care setting. Patients and Setting. All hospice patients admitted to a North …

Methadone hydrochloride is an old drug that has been in vogue off and on. It has complex
pharmacodynamics and can be potentially fatal in inexperienced settings. Drug switching …

Background: Methadone offers many advantages for treating cancer pain. However, its
pharmacokinetic profile makes its use as a full-dose opioid challenging. Objectives: To …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

Background: Opioid dose escalation may cause hyperalgesia, mediated by the N-methyl-D-
aspartate (NMDA) pathway. Methadone is an atypical opioid that inhibits hyperalgesia …

Since the 2014 Amendment to the NDPS Act methadone has been released in India for pain
management. The methadone is supplied as racemic mixture with R & S methadone with …

The aim of this review is to summarize the current knowledge of low-dose methadone
treatment in palliative cancer care. In Sweden, methadone is quite common in specialized …