[HTML][HTML] From cell lines to pluripotent stem cells for modelling Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …
[HTML][HTML] Human brain-based models provide a powerful tool for the advancement of Parkinson's disease research and therapeutic development
SF McComish, AN MacMahon Copas… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease and
affects approximately 2–3% of the population over the age of 65. PD is characterised by the …
affects approximately 2–3% of the population over the age of 65. PD is characterised by the …
Induced pluripotent stem cells: a tool for modeling Parkinson's disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. Among
its pathologies, progressive loss of dopaminergic (DA) neurons in the substantia nigra is …
its pathologies, progressive loss of dopaminergic (DA) neurons in the substantia nigra is …
Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery
Introduction: Parkinson's disease is a devastating neurodegenerative disorder preferentially
involving loss of dopaminergic neurons in the substantia nigra, leading to typical motor …
involving loss of dopaminergic neurons in the substantia nigra, leading to typical motor …
Parkinson's disease in a dish–using stem cells as a molecular tool
JL Badger, O Cordero-Llana, EM Hartfield… - …, 2014 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease, with a
strong genetic component to both the familial and sporadic forms. The cardinal motor …
strong genetic component to both the familial and sporadic forms. The cardinal motor …
Solving the puzzle of Parkinson's disease using induced pluripotent stem cells
The prevalence and incidence of Parkinson's disease (PD) is increasing due to a prolonged
life expectancy. This highlights the need for a better mechanistic understanding and new …
life expectancy. This highlights the need for a better mechanistic understanding and new …
[HTML][HTML] Modelling Parkinson's disease: iPSCs towards better understanding of human pathology
S Avazzadeh, JM Baena, C Keighron… - Brain Sciences, 2021 - mdpi.com
Parkinson's Disease (PD) is a chronic neurodegenerative disorder characterized by motor
and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental …
and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental …
[HTML][HTML] Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
M Pons-Espinal, L Blasco-Agell, A Consiglio - Cellular and Molecular Life …, 2021 - Springer
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with
characteristic movement impairments that are caused by the progressive loss of dopamine …
characteristic movement impairments that are caused by the progressive loss of dopamine …
Stem Cells as In Vitro Model of Parkinson′s Disease
PL Martínez-Morales, I Liste - Stem cells international, 2012 - Wiley Online Library
Progress in understanding neurodegenerative cell biology in Parkinson′ s disease (PD)
has been hampered by a lack of predictive and relevant cellular models. In addition, the lack …
has been hampered by a lack of predictive and relevant cellular models. In addition, the lack …
[HTML][HTML] One step into the future: new iPSC tools to advance research in Parkinson's disease and neurological disorders
NV Mohamed, F Larroquette, LK Beitel… - Journal of …, 2019 - content.iospress.com
Studying Parkinson's disease (PD) in the laboratory presents many challenges, the main
one being the limited availability of human cells and tissue from affected individuals. As PD …
one being the limited availability of human cells and tissue from affected individuals. As PD …