[HTML][HTML] From cell lines to pluripotent stem cells for modelling Parkinson's Disease

E Ferrari, A Cardinale, B Picconi, F Gardoni - Journal of Neuroscience …, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …

[HTML][HTML] Human brain-based models provide a powerful tool for the advancement of Parkinson's disease research and therapeutic development

SF McComish, AN MacMahon Copas… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease and
affects approximately 2–3% of the population over the age of 65. PD is characterised by the …

Induced pluripotent stem cells: a tool for modeling Parkinson's disease

A Bose, GA Petsko, L Studer - Trends in neurosciences, 2022 - cell.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. Among
its pathologies, progressive loss of dopaminergic (DA) neurons in the substantia nigra is …

Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery

N Marotta, S Kim, D Krainc - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction: Parkinson's disease is a devastating neurodegenerative disorder preferentially
involving loss of dopaminergic neurons in the substantia nigra, leading to typical motor …

Parkinson's disease in a dish–using stem cells as a molecular tool

JL Badger, O Cordero-Llana, EM Hartfield… - …, 2014 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease, with a
strong genetic component to both the familial and sporadic forms. The cardinal motor …

Solving the puzzle of Parkinson's disease using induced pluripotent stem cells

P Zhao, Z Luo, W Tian, J Yang… - Experimental …, 2014 - journals.sagepub.com
The prevalence and incidence of Parkinson's disease (PD) is increasing due to a prolonged
life expectancy. This highlights the need for a better mechanistic understanding and new …

[HTML][HTML] Modelling Parkinson's disease: iPSCs towards better understanding of human pathology

S Avazzadeh, JM Baena, C Keighron… - Brain Sciences, 2021 - mdpi.com
Parkinson's Disease (PD) is a chronic neurodegenerative disorder characterized by motor
and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental …

[HTML][HTML] Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells

M Pons-Espinal, L Blasco-Agell, A Consiglio - Cellular and Molecular Life …, 2021 - Springer
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with
characteristic movement impairments that are caused by the progressive loss of dopamine …

Stem Cells as In Vitro Model of Parkinson′s Disease

PL Martínez-Morales, I Liste - Stem cells international, 2012 - Wiley Online Library
Progress in understanding neurodegenerative cell biology in Parkinson′ s disease (PD)
has been hampered by a lack of predictive and relevant cellular models. In addition, the lack …

[HTML][HTML] One step into the future: new iPSC tools to advance research in Parkinson's disease and neurological disorders

NV Mohamed, F Larroquette, LK Beitel… - Journal of …, 2019 - content.iospress.com
Studying Parkinson's disease (PD) in the laboratory presents many challenges, the main
one being the limited availability of human cells and tissue from affected individuals. As PD …