Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis

JA Hammond, EA Gordon, KM Socarras… - Biochemical Society …, 2020 - portlandpress.com
The principle of monoclonality with regard to bacterial infections was considered immutable
prior to 30 years ago. This view, espoused by Koch for acute infections, has proven …

Host biology in light of the microbiome: ten principles of holobionts and hologenomes

SR Bordenstein, KR Theis - PLoS biology, 2015 - journals.plos.org
Groundbreaking research on the universality and diversity of microorganisms is now
challenging the life sciences to upgrade fundamental theories that once seemed …

Of genes and microbes: solving the intricacies in host genomes

J Wang, L Chen, N Zhao, X Xu, Y Xu, B Zhu - Protein & Cell, 2018 - academic.oup.com
Microbiome research is a quickly developing field in biomedical research, and we have
witnessed its potential in understanding the physiology, metabolism and immunology, its …

Our unique microbial identity

JA Gilbert - Genome biology, 2015 - Springer
Our unique microbial identity | Genome Biology Skip to main content SpringerLink Account Menu
Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome Biology …

Microbial genomics challenge Darwin

D Raoult, EV Koonin - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
This collection of 14 articles in Frontiers in Cellular and Infectious Microbiology aims to re-
assess Darwinian and neo-darwinian concepts of biological evolution in the light of the …

Gene transfer, speciation, and the evolution of bacterial genomes

JG Lawrence - Current opinion in microbiology, 1999 - Elsevier
Studies in microbial evolution have focused on the origin and vertical transmission of
genetic variation within populations experiencing limited recombination. Genomic analyses …

Extensive Genomic Plasticity in Pseudomonas aeruginosa Revealed by Identification and Distribution Studies of Novel Genes among Clinical Isolates

K Shen, S Sayeed, P Antalis, J Gladitz… - Infection and …, 2006 - Am Soc Microbiol
The distributed genome hypothesis (DGH) states that each strain within a bacterial species
receives a unique distribution of genes from a population-based supragenome that is many …

[PDF][PDF] Genomes in motion: gene transfer as a catalyst for genome change

JG Lawrence, H Hendrickson - … gene transfer in the evolution of …, 2008 - researchgate.net
Despite our interest and motivation, bacteria are not particularly easy organisms to study;
their niches are complex and poorly understood and the vast majority of these species are …

Insights from genomics into bacterial pathogen populations

DJ Wilson - 2012 - journals.plos.org
Bacterial pathogens impose a heavy burden of disease on human populations worldwide.
The gravest threats are posed by highly virulent respiratory pathogens, enteric pathogens …

Horizontal and vertical gene transfer: the life history of pathogens

JG Lawrence - Concepts in Bacterial Virulence, 2005 - karger.com
Viewpoints regarding the evolution of pathogenic bacteria have themselves evolved over
the past two decades. Although it is perhaps extreme to suggest different teleological camps …