Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

The understanding of nitric oxide (NO) signaling has grown substantially since the
identification of endothelial derived relaxing factor (EDRF). NO has emerged as a ubiquitous …

Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular
system. Each of the enzymes that generate NO—neuronal, inducible and endothelial NO …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Nitric oxide (NO) is an intra-and extracellular messenger that mediates diverse signaling
pathways in target cells and is known to play an important role in many physiological …

Nitric oxide (NO) mediates multiple physiological and pathophysiological processes in the
cardiovascular system. Pharmacological compounds that release NO have been useful tools …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Nitric oxide (NO) exerts a variety of biological actions under both physiological and
pathological conditions. NO is synthesized by three distinct NO synthase (NOS) isoforms …