[HTML][HTML] Production of L-carnitine by secondary metabolism of bacteria

V Bernal, Á Sevilla, M Cánovas, JL Iborra - Microbial Cell Factories, 2007 - Springer
The increasing commercial demand for L-carnitine has led to a multiplication of efforts to
improve its production with bacteria. The use of different cell environments, such as growing …

[HTML][HTML] Metabolic engineering for high yielding L(-)-carnitine production in Escherichia coli

P Arense, V Bernal, D Charlier, JL Iborra… - Microbial Cell …, 2013 - Springer
Abstract Background L (-)-carnitine production has been widely studied because of its
beneficial properties on various diseases and dysfunctions. Enterobacteria possess a …

High-density Escherichia coli cultures for continuous l(−)-carnitine production

JM Obón, JR Maiquez, M Cánovas, HP Kleber… - Applied microbiology …, 1999 - Springer
The use of a biological procedure for l-carnitine production as an alternative to chemical
methods must be accompanied by an efficient and highly productive reaction system …

L (-)-carnitine production using a recombinant Escherichia coli strain

MR Castellar, JM Obón, A Marán, M Cánovas… - Enzyme and microbial …, 2001 - Elsevier
The L (-)-carnitine production by biotransformation using the recombinant strain Escherichia
coli pT7-5KE32 has been studied and optimized with crotonobetaine and D (+)-carnitine as …

Role of energetic coenzyme pools in the production of L-carnitine by Escherichia coli

M Cánovas, A Sevilla, V Bernal, R Leal, JL Iborra - Metabolic Engineering, 2006 - Elsevier
The aim of this work was to understand the steps controlling the biotransformation of
trimethylammonium compounds into l (-)-carnitine by Escherichia coli. The high-cell density …

Bacterial carnitine metabolism

HP Kleber - FEMS microbiology letters, 1997 - academic.oup.com
Abstract l-(−)-Carnitine is a ubiquitously occurring substance, essential for the transport of
long-chain fatty acids through the inner mitochondrial membrane. Bacteria are able to …

Design of Metabolic Engineering Strategies for Maximizing l‐(–)‐Carnitine Production by Escherichia coli. Integration of the Metabolic and Bioreactor Levels

A Sevilla, J Vera, Z Díaz, M Cánovas… - Biotechnology …, 2005 - Wiley Online Library
In this work metabolic engineering strategies for maximizing l‐(–)‐carnitine production by
Escherichia coli based on the Biochemical System Theory (1–3) and the Indirect …

Metabolism of L (−)-carnitine by Enterobacteriaceae under aerobic conditions

T Elßner, A Preußer, U Wagner… - FEMS microbiology …, 1999 - academic.oup.com
Abstract Different Enterobacteriaceae, such as Escherichia coli, Proteus vulgaris and
Proteus mirabilis, are able to convert L (−)-carnitine, via crotonobetaine, into γ-butyrobetaine …

Biotransformation of D(+)–carnitine into L(−)–carnitine by resting cells of Escherichia coli O44 K74

MR Castellar, M Cánovas, HP Kleber… - Journal of applied …, 1998 - academic.oup.com
Abstract l (−)‐carnitine was produced from d (+)‐carnitine by resting cells of Escherichia coli
O44 K74. Oxygen did not inhibit either the carnitine transport system or the enzymes …

Modeling, optimization and experimental assessment of continuous L‐(−)‐carnitine production by Escherichia coli cultures

F Alvarez‐Vasquez, M Canovas… - Biotechnology and …, 2002 - Wiley Online Library
In a previous paper Cánovas et al.(Biotechnol Bioeng 2002; 77: 764–775) presented a
model for L-(−)-carnitine production using Escherichia coli O44 K74, in a cell-recycle …