Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study
Importance Observational studies have reported associations between antihypertensive
medication and psychiatric disorders, although the reported direction of association appears …
medication and psychiatric disorders, although the reported direction of association appears …
Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?
DF Levinson, S Mostafavi… - Biological …, 2014 - biologicalpsychiatryjournal.com
Over the past 5 years, the genome-wide association study (GWAS) method has produced
significant findings that are providing insights into the biological pathways involved in …
significant findings that are providing insights into the biological pathways involved in …
Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to lithium in bipolar affective disorder: a genome-wide …
Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30 …
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30 …
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …
genetic associations with such disorders, but better methods are needed to derive the …
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Objective: Family and twin studies indicate substantial overlap of genetic influences on
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
psychotic and mood disorders. Linkage and candidate gene studies have also suggested …
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Cross-Disorder Group of the Psychiatric Genomics … - The Lancet, 2013 - Elsevier
BACKGROUND: Findings from family and twin studies suggest that genetic contributions to
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics
A genome-wide association (GWA) study of treatment outcomes (response and remission) of
selective serotonin reuptake inhibitors (SSRIs) was conducted using 529 subjects with major …
selective serotonin reuptake inhibitors (SSRIs) was conducted using 529 subjects with major …
Schizophrenia polygenic risk score as a predictor of antipsychotic efficacy in first-episode psychosis
JP Zhang, D Robinson, J Yu, J Gallego… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Pharmacogenomic studies of antipsychotics have typically examined effects of
individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome …
individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome …
A framework for interpreting genome-wide association studies of psychiatric disorders.
P Sullivan - Molecular psychiatry, 2009 - psycnet.apa.org
Genome-wide association studies (GWAS) have yielded a plethora of new findings in the
past 3 years. By early 2009, GWAS on 47 samples of subjects with attention-deficit …
past 3 years. By early 2009, GWAS on 47 samples of subjects with attention-deficit …