Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
[HTML][HTML] Neutralizing type I interferon autoantibodies in Japanese patients with severe COVID-19
S Eto, Y Nukui, M Tsumura, Y Nakagama… - Journal of Clinical …, 2022 - Springer
Purpose Autoantibodies (aAbs) to type I interferons (IFNs) have been found in less than 1%
of individuals under the age of 60 in the general population, with the prevalence increasing …
of individuals under the age of 60 in the general population, with the prevalence increasing …
[HTML][HTML] Neutralizing autoantibodies to type I IFNs in> 10% of patients with severe COVID-19 pneumonia hospitalized in Madrid, Spain
J Troya, P Bastard, L Planas-Serra, P Ryan… - Journal of clinical …, 2021 - Springer
Background In a recent study, autoantibodies neutralizing type I interferons (IFNs) were
present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies …
present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies …
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients
D Goncalves, M Mezidi, P Bastard… - Clinical & …, 2021 - Wiley Online Library
Objectives Impairment of type I interferon (IFN‐I) immunity has been reported in critically ill
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
COVID‐19 patients. This defect can be explained in a subset of patients by the presence of …
Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19
MS Abers, LB Rosen, OM Delmonte… - Immunology and cell …, 2021 - Wiley Online Library
Type‐I interferons (IFNs) mediate antiviral activity and have emerged as important immune
mediators during coronavirus disease 19 (COVID‐19). Several lines of evidence suggest …
mediators during coronavirus disease 19 (COVID‐19). Several lines of evidence suggest …
[HTML][HTML] Autoantibodies neutralizing type I interferons in 20% of COVID-19 deaths in a French hospital
A Chauvineau-Grenier, P Bastard, A Servajean… - Journal of Clinical …, 2022 - Springer
Recent studies reported the presence of pre-existing autoantibodies (auto-Abs) neutralizing
type I interferons (IFNs) in at least 15% of patients with critical COVID-19 pneumonia. In one …
type I interferons (IFNs) in at least 15% of patients with critical COVID-19 pneumonia. In one …
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
P Bastard, SE Vazquez, J Liu, MT Laurie… - Science …, 2023 - science.org
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning
antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting …
antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting …
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain… - Science …, 2021 - science.org
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1: 10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID …
diluted 1: 10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID …
[HTML][HTML] Pre-existing autoantibodies neutralizing high concentrations of type I interferons in almost 10% of COVID-19 patients admitted to intensive care in Barcelona
X Solanich, R Rigo-Bonnin, VD Gumucio… - Journal of clinical …, 2021 - Springer
Background It is important to predict which patients infected by SARS-CoV-2 are at higher
risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies …
risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies …
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19
MGP van der Wijst, SE Vazquez… - Science translational …, 2021 - science.org
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …
patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe …