Background—T-wave alternans, which is associated with the genesis of cardiac fibrillation,
has recently been related to discordant action potential duration (APD) alternans. However …

Discordant Alternans Mechanism. Introduction: Discordant alternans has the potential to
produce larger alternans of the ECG T wave than concordant alternans, but its mechanism is …

Alternans of action potential duration has been associated with T wave alternans and the
development of arrhythmias because it produces large gradients of repolarization. However …

Computer simulations and nonlinear dynamics have provided invaluable tools for
illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this …

Previously, using an animal model of T-wave alternans in structurally normal myocardium,
we demonstrated that repolarization can alternate with opposite phase between neighboring …

T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action
potential duration (APD). The underlying cellular mechanism of APD alternans is unknown …

Background—Spatially discordant alternans (SDA) has been linked to life-threatening
arrhythmias. The mechanisms underlying SDA development in cardiac tissue remain …

Restitution and Spatial Heterogeneities vs Arrhythmias. Introduction: The slope of the action
potential duration (APD) restitution curve has been used to explain wavebreaks during …

Spatially discordant alternans, where the action potential duration (APD) and intracellular
calcium transient (Cai) alternate with opposite phase in different regions of tissue, is known …

Pre-existing heterogeneities present in cardiac tissue are essential for maintaining the
normal electrical and mechanical functions of the heart. Exacerbation of such …