Neurodegenerative diseases, such as Alzheimer's disease Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis, share a common cellular and …

The most prevalent pathological features of many neurodegenerative diseases are the
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …

The most prevalent neurodegenerative disorders involve protein misfolding and the
aggregation of specific proteins. Autophagy is becoming an attractive target to treat …

Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis,
has recently been the focus of numerous human diseases and conditions, such as aging …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Autophagy is a lysosome-dependent intracellular degradation process that allows recycling
of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss due to aberrant accumulation of misfolded proteins inside and outside neurons …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Autophagy is an intracellular degradation process responsible for the clearance of most long-
lived proteins and organelles. Cytoplasmic components are enclosed by double-membrane …