An electrostatic layer-by-layer self-assembly technique was used to encapsulate solid core
paclitaxel nanoparticles within a polymeric nanometer-scale shell. This approach provides a …

Paclitaxel, an antimicrotubular agent used in the treatment of ovarian and breast cancer,
was encapsulated in nanoparticles of poly (DL-lactide-co-glycolide) and poly (ε …

The main challenge encountered while treating using Paclitaxel (PTX) is its poor solubility in
aqueous solutions. The cremophor used in the formulation can cause various side effects …

Introduction An increasing research interest has been directed toward nanoparticle-based
drug delivery systems for their advantages. The appropriate amalgamation of pH sensitivity …

Paclitaxel is a microtubule inhibitor causing mitotic arrest and is widely used in cancer
chemotherapy. However, its poor water solubility restricts its direct clinical applications. In …

Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades,
which has been found effective against a wide spectrum of cancers including ovarian …

The present study was designed to explore the ability of polymeric nanoparticles to restore
drug sensitivity to P-glycoprotein over-expressing cancer cells. A multidrug-resistant cell line …

Objective: The purpose of this work was to prepare a stable paclitaxel nanosuspension and
test it for potential use as a targeted chemotherapeutic. Different particle coatings were …

Recent studies focused on the nanodelivery system of paclitaxel (Ptx) to overcome the poor
solubility and hypersensitivity of Ptx caused by the application of Cremophor EL as a …

Nanoencapsulation is a promising solution for the delivery of chemotherapeutics to tumors.
A method of preparation of drug-loaded nanocapsules based on the liquid core …