Towards precision oncology in advanced prostate cancer
Metastatic biopsy programmes combined with advances in genomic sequencing have
provided new insights into the molecular landscape of castration-resistant prostate cancer …
provided new insights into the molecular landscape of castration-resistant prostate cancer …
Genomic testing in patients with metastatic castration-resistant prostate cancer: a pragmatic guide for clinicians
AS Merseburger, N Waldron, MJ Ribal, A Heidenreich… - European Urology, 2021 - Elsevier
Context Genomic testing is becoming increasingly important in patients with advanced
prostate cancer (PC) and is being incorporated in clinical practice to guide treatment …
prostate cancer (PC) and is being incorporated in clinical practice to guide treatment …
Drug discovery in advanced prostate cancer: translating biology into therapy
TA Yap, AD Smith, R Ferraldeschi… - Nature reviews Drug …, 2016 - nature.com
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses
considerable therapeutic challenges. Recent genetic and technological advances have …
considerable therapeutic challenges. Recent genetic and technological advances have …
Mechanisms of therapeutic resistance in prostate cancer
M Nakazawa, C Paller, N Kyprianou - Current oncology reports, 2017 - Springer
Prostate cancer is the second leading cause of cancer deaths in the USA. The challenge in
managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic …
managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic …
Biallelic inactivation of BRCA2 in platinum-sensitive metastatic castration-resistant prostate cancer
HH Cheng, CC Pritchard, T Boyd, PS Nelson… - European urology, 2016 - Elsevier
Understanding the molecular underpinnings of sensitivity to specific therapies will advance
the goal of precision medicine in prostate cancer (PCa). We identified three patients with …
the goal of precision medicine in prostate cancer (PCa). We identified three patients with …
Biological evolution of castration-resistant prostate cancer
Context Recent studies focused on the molecular characterization of metastatic prostate
cancer have identified genomic subsets and emerging resistance patterns. Detection of …
cancer have identified genomic subsets and emerging resistance patterns. Detection of …
Update on systemic prostate cancer therapies: management of metastatic castration-resistant prostate cancer in the era of precision oncology
P Nuhn, JS De Bono, K Fizazi, SJ Freedland, M Grilli… - European urology, 2019 - Elsevier
Context Introduction of novel agents for the management of advanced prostate cancer
provides a range of treatment options with notable benefits for men with metastatic castration …
provides a range of treatment options with notable benefits for men with metastatic castration …
New therapies for castration-resistant prostate cancer: efficacy and safety
Abstract Context Prostate cancer (PCa) is the most common noncutaneous malignancy and
the second leading cause of cancer mortality amongst men in the Western world. Up to 40 …
the second leading cause of cancer mortality amongst men in the Western world. Up to 40 …
Trial design and objectives for castration-resistant prostate cancer: updated recommendations from the Prostate Cancer Clinical Trials Working Group 3
HI Scher, MJ Morris, WM Stadler, C Higano… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Evolving treatments, disease phenotypes, and biology, together with a changing
drug development environment, have created the need to revise castration-resistant prostate …
drug development environment, have created the need to revise castration-resistant prostate …
Genomics of lethal prostate cancer at diagnosis and castration resistance
The genomics of primary prostate cancer differ from those of metastatic castration-resistant
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …
prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer …
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