Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

Acute spinal cord injury (SCI) produces tissue damage that continues to evolve days and
weeks after the initial insult, with corresponding functional impairments. Reducing the extent …

Minocycline, a clinically used tetracycline for over 40 years, crosses the blood–brain barrier
and prevents caspase up‐regulation. It reduces apoptosis in mouse models of Huntington's …

Study design. A prospective, randomized experimental research. Objective. To evaluate the
short-and long-term neuroprotective effects of minocycline on the secondary injury process …

We examined the effects of minocycline, an anti-inflammatory drug, on functional recovery
following spinal cord injury (SCI). Rats received a mild, weight-drop contusion injury to the …

This study was initiated due to an NIH “Facilities of Research—Spinal Cord Injury” contract
to support independent replication of published studies that could be considered for a …

Several studies have shown that minocycline, a semisynthetic, second-generation
tetracycline derivative, is neuroprotective in animal models of central nervous system trauma …

Minocycline (MC), a second-generation tetracycline and anti-inflammatory agent reportedly
provides neuroprotection following CNS injury. The objective of this study was to examine …

Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI).
However, the cellular consequences of minocycline treatment on the secondary injury …

Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline.
Animal studies and early clinical trials support its use in several neurological diseases. In …