Contemporary perspectives on the genetics and clinical use of lipoprotein (a) in preventive cardiology

MM Page, GF Watts - Current Opinion in Cardiology, 2021 - journals.lww.com
Measurement of Lp (a) in the clinical setting contributes to the assessment of ASCVD risk,
and will become more important with the advent of specific Lp (a)-lowering therapies …

Is Lipoprotein (a) Clinically Actionable with Today's Evidence? The Answer is Yes

GS Ma, TT Chiou, MJ Wilkinson - Current Cardiology Reports, 2023 - Springer
Abstract Purpose of Review Lipoprotein (a) is an independent risk factor for cardiovascular
disease. We review the ongoing shifts in consensus guidelines for the testing and …

Lipoprotein (a): when to measure and how to treat?

D Rhainds, MR Brodeur, JC Tardif - Current Atherosclerosis Reports, 2021 - Springer
Abstract Purpose of Review The purpose of this article is to review current evidence for
lipoprotein (a)(Lp (a)) as a risk factor for multiple cardiovascular (CV) disease phenotypes …

[HTML][HTML] Lipoprotein (a): An important piece of the ASCVD risk factor puzzle across diverse populations

N Ciffone, CJ McNeal, MP McGowan… - American Heart Journal …, 2023 - Elsevier
Abstract Elevated lipoprotein (a)(Lp [a]) is an independent, genetic risk factor for
atherosclerotic cardiovascular disease (ASCVD) that impacts~ 1.4 billion people globally …

Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …

S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …

Screening for and management of elevated Lp (a)

MB Boffa, ML Koschinsky - Current cardiology reports, 2013 - Springer
Abstract While lipoprotein (a)(Lp (a)) has long been an intriguing subject for basic
researchers and clinicians alike, it is only recently that this unique cardiovascular risk factor …

Lipoprotein (a) as a therapeutic target in cardiovascular disease

M Koschinsky, M Boffa - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: Recent advances in genetics and epidemiology have once again thrust
lipoprotein (a)(Lp (a)) into the clinical spotlight. Elevated plasma concentrations of Lp (a) are …

[HTML][HTML] High lipoprotein (a): actionable strategies for risk assessment and mitigation

G Reyes-Soffer, C Yeang, ED Michos… - American Journal of …, 2024 - Elsevier
High levels of lipoprotein (a)[Lp (a)] are causal for atherosclerotic cardiovascular disease
(ASCVD). Lp (a) is the most prevalent inherited dyslipidemia and strongest genetic ASCVD …

Genetic predictor to identify individuals with high lipoprotein (a) concentrations

JS Dron, M Wang, AP Patel, U Kartoun… - Circulation: Genomic …, 2021 - Am Heart Assoc
Recent advances in drug development aim to transi-tion lipoprotein (a)(Lp [a]) from a
predictive biomarker of cardiovascular disease to a therapeutic target. Among those with …

Lipoprotein (a) and cardiovascular disease: sifting the evidence to guide future research

PR Kamstrup, RDG Neely, S Nissen… - European Journal of …, 2024 - academic.oup.com
Abstract Lipoprotein (a)(Lp (a)) is a genetically determined causal risk factor for
cardiovascular disease including coronary heart disease, peripheral arterial disease …