Although some studies have suggested that relapse may be associated with antipsychotic
treatment resistance in schizophrenia, the number and quality of studies is limited. The …

This study investigated whether illness progression and treatment refractoriness emerge
after relapse in schizophrenia. We compared outcomes in a cohort treated with a …

Objective: The authors examined early onset of antipsychotic action and early prediction of
nonresponse to antipsychotics in patients with first-episode schizophrenia. Method: Time to …

Background We examined relapse after response to a first episode of schizophrenia or
schizoaffective disorder. Methods Patients with first-episode schizophrenia were assessed …

Objective An important clinical question is how many patients with acute schizophrenia do
not respond to antipsychotics despite being treated for adequate time and with an effective …

Our objective was to prospectively assess whether early (ie, 2 weeks) response to an
antipsychotic predicts later (12-week) response and whether 'switching'early non …

Background Multiple relapses characterise the course of illness in most patients with
schizophrenia, yet the nature of these episodes has not been extensively researched and …

Objective: It is generally believed that after the first episode of schizophrenia, the risk of
relapse decreases with time in patients who are stabilized. Many treatment guidelines …

Objective: To examine the course and potential predictors of treatment response in the early
phase of schizophrenia. Design: Prospective study of an inception cohort. Setting …

Objective: How long clinicians should wait before considering an antipsychotic ineffective
and changing treatment in schizophrenia is an unresolved clinical question. Guidelines …