Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management …
A Paniccia, PM Polanco, BA Boone, AI Wald… - Gastroenterology, 2023 - Elsevier
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts
Background and Aims The value of next-generation sequencing (NGS) of pancreatic cyst
fluid relative to the clinical and imaging impression has not been well-studied. The aim of …
fluid relative to the clinical and imaging impression has not been well-studied. The aim of …
Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …
A combination of molecular markers and clinical features improve the classification of pancreatic cysts
Background & Aims The management of pancreatic cysts poses challenges to both patients
and their physicians. We investigated whether a combination of molecular markers and …
and their physicians. We investigated whether a combination of molecular markers and …
Next‐generation sequencing adds value to the preoperative diagnosis of pancreatic cysts
MW Rosenbaum, M Jones, JC Dudley… - Cancer …, 2017 - Wiley Online Library
BACKGROUND The diagnosis of a pancreatic cyst as mucinous or high‐risk dictates the
need for follow‐up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) …
need for follow‐up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) …
Predictive ability of pancreatic cyst fluid biomarkers: a systematic review and meta-analysis
Background Mucinous pancreatic cysts harbor the potential to progress to highly lethal
pancreatic ductal adenocarcinoma (PDAC). Since these precursor cysts require cancer …
pancreatic ductal adenocarcinoma (PDAC). Since these precursor cysts require cancer …
American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients …
Background and Aims The American Gastroenterological Association (AGA) recently
reported evidence-based guidelines for the management of asymptomatic neoplastic …
reported evidence-based guidelines for the management of asymptomatic neoplastic …
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology
Background & Aims: Current methods to detect malignancy in mucinous cystic neoplasms of
the pancreas remain inadequate. The role of detailed molecular analysis in this context was …
the pancreas remain inadequate. The role of detailed molecular analysis in this context was …
Comparison of society guidelines for the management and surveillance of pancreatic cysts: a review
H Aziz, AW Acher, SG Krishna, JM Cloyd… - JAMA …, 2022 - jamanetwork.com
Importance The identification of incidental pancreas cystic lesions (PCLs) has increased in
recent decades with the expanded use and improved sensitivity of cross-sectional imaging …
recent decades with the expanded use and improved sensitivity of cross-sectional imaging …
Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis
J Shen, WR Brugge, CJ DiMaio… - Cancer …, 2009 - Wiley Online Library
BACKGROUND: The management of patients with pancreatic cysts is based on the
preoperative distinction of nonmucinous and mucinous cysts in general and of benign and …
preoperative distinction of nonmucinous and mucinous cysts in general and of benign and …