The uterine cervix plays two important but opposing roles during pregnancy–as a
mechanical barrier that maintains the fetus for nine months and as a compliant structure that …

The uterine cervix plays two important but opposing roles during pregnancy–as a
mechanical barrier that maintains the fetus for nine months and as a compliant structure that …

Appropriate mechanical function of the uterine cervix is critical for maintaining a pregnancy
to term so that the fetus can develop fully. At the end of pregnancy, however, the cervix must …

The uterine cervix undergoes a complex remodelling process during pregnancy,
characterized by dramatic changes in both extracellular matrix (ECM) structure and …

Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic
pathways culminate in the final common denominator of cervical softening, shortening, and …

Through pregnancy the cervix must simultaneously remain competent for pregnancy
maintenance and yet become progressively compliant to ensure on time parturition. Cervical …

Cervical insufficiency is a significant obstetrical complication that causes preterm birth. The
current treatment of cervical insufficiency is cerclage surgery. A cerclage is a suture that is …

Major clinical challenges for obstetricians and neonatologists result from early cervix
remodeling and preterm birth. Complications related to cervix remodeling or delivery …

Approximately one in ten (approximately 500,000) pregnancies results in preterm birth (PTB)
annually in the United States. Although we have seen a slight decrease in the US PTB rate …

The cervix plays an integral part in ensuring the proper timing of pregnancy and parturition. It
maintains the fetus within the uterus and protects it from pathogens present in the vaginal …