Background Observational studies have suggested an association between multiple
sclerosis (MS) and cortical structure, but the results have been inconsistent. Objective We …

Multiple sclerosis (MS) is characterized by temporal and spatial dissemination of
demyelinating lesions in the central nervous system. Associated neurodegenerative …

Background: Multiple sclerosis (MS) affects brain structure and cognitive function and has a
heritable component. Over a 100 common genetic risk variants have been identified, but …

Background: The relationship between structural and functional deficits in multiple sclerosis
(MS) is unclear. Objective: This study explored structure-function relationships during the 5 …

Objectives We conducted a systematic review and wide-angled Mendelian randomization
(MR) study to examine the association between possible risk factors and multiple sclerosis …

Objective Vascular comorbidities are associated with reduced cognitive performance and
with changes in brain structure in people with multiple sclerosis (MS). Understanding causal …

Background: Although a more favorable course of multiple sclerosis is associated with a low
degree of cortical pathology, only longitudinal studies could definitely confirm this …

Background Processing speed (PS) decline is the most commonly observed cognitive deficit
in people with multiple sclerosis (MS) resulting in a significant impact on quality of life …

Background: Cortical lesion subtypes' occurrence and distribution across networks may
shed light on cognitive impairment (CI) in multiple sclerosis (MS). Methods: In 332 people …

While the genetics of MS risk susceptibility are well-described, and recent progress has
been made on the genetics of disease severity, the genetics of disease progression remain …