Malaria's deadly grip: cytoadhesion of Plasmodium falciparum‐infected erythrocytes
Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to host microvasculature is a
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …
key virulence determinant. Parasite binding is mediated by a large family of clonally variant …
Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion
R Noviyanti, GV Brown, ME Wickham, MF Duffy… - Molecular and …, 2001 - Elsevier
Adherence of Plasmodium falciparum-infected erythrocytes to the post-capillary endothelium
is an important characteristic of malaria infection. The adhesion is mediated predominantly …
is an important characteristic of malaria infection. The adhesion is mediated predominantly …
A family affair: var genes, PfEMP1 binding, and malaria disease
SM Kraemer, JD Smith - Current opinion in microbiology, 2006 - Elsevier
An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research
JD Smith - Molecular and biochemical parasitology, 2014 - Elsevier
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family
SM Kraemer, JD Smith - Molecular microbiology, 2003 - Wiley Online Library
The var gene family encodes Plasmodium falciparum erythrocyte membrane 1 (PfEMP1)
proteins that act as virulence factors responsible for both antigenic variation and …
proteins that act as virulence factors responsible for both antigenic variation and …
Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surface
M Tibúrcio, F Silvestrini, L Bertuccini… - Cellular …, 2013 - Wiley Online Library
In P lasmodium falciparum infections the parasite transmission stages, the gametocytes,
mature in 10 days sequestered in internal organs. Recent studies suggest that cell …
mature in 10 days sequestered in internal organs. Recent studies suggest that cell …
Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope
C Mayer, L Slater, MC Erat, R Konrat… - Journal of Biological …, 2012 - ASBMB
Plasmodium falciparum-infected red blood cells adhere to endothelial cells, thereby
obstructing the microvasculature. Erythrocyte adherence is directly associated with severe …
obstructing the microvasculature. Erythrocyte adherence is directly associated with severe …
Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1
L Joergensen, DC Bengtsson, A Bengtsson… - PLoS …, 2010 - journals.plos.org
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
PfEMP1-DBL1α amino acid motifs in severe disease states of Plasmodium falciparum malaria
An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive
binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by …
binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by …
Virulence of Malaria Is Associated with Differential Expression of Plasmodium falciparum var Gene Subgroups in a Case-Control Study
M Kaestli, IA Cockburn, A Cortés, K Baea… - The Journal of …, 2006 - academic.oup.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity
factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by∼ 60 var …
factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by∼ 60 var …