Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth
Background Increased expression of the complement component 4A (C4A) gene is
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
Beyond C4: Analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls
JF Holland, D Cosgrove, L Whitton… - Genes, Brain and …, 2019 - Wiley Online Library
Variation in cognitive performance, which strongly predicts functional outcome in
schizophrenia (SZ), has been associated with multiple immune‐relevant genetic loci. These …
schizophrenia (SZ), has been associated with multiple immune‐relevant genetic loci. These …
The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders
Complement components have been linked to schizophrenia and autoimmune disorders.
We examined the association between neonatal circulating C3 and C4 protein …
We examined the association between neonatal circulating C3 and C4 protein …
Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
AbstractBackground Altered expression of the complement component C4A gene is a
known risk factor for schizophrenia. Further, predicted brain C4A expression has also been …
known risk factor for schizophrenia. Further, predicted brain C4A expression has also been …
Genetically predicted brain C4A expression is associated with TSPO and hippocampal morphology
Background Alterations in the immune system, particularly C4A, have been implicated in the
pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in …
pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in …
A structural brain network of genetic vulnerability to psychiatric illness
Psychiatry is undergoing a paradigm shift from the acceptance of distinct diagnoses to a
representation of psychiatric illness that crosses diagnostic boundaries. How this transition …
representation of psychiatric illness that crosses diagnostic boundaries. How this transition …
[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders
Abstract Background 22q11. 2 copy number variants are among the most highly penetrant
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
genetic risk variants for developmental neuropsychiatric disorders such as schizophrenia …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
Functional connectome-wide associations of schizophrenia polygenic risk
Schizophrenia is a highly heritable mental disorder characterized by functional
dysconnectivity across the brain. However, the relationships between polygenic risk factors …
dysconnectivity across the brain. However, the relationships between polygenic risk factors …