[HTML][HTML] Targeting transcription factors for therapeutic benefit in rheumatoid arthritis

T Balendran, K Lim, JA Hamilton… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …

Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy

SW Tas, PHJ Remans, KA Reedquist… - Current pharmaceutical …, 2005 - ingentaconnect.com
Many chronic inflammatory diseases are associated with deregulated intracellular signal
transduction pathways. Resultant pathogenic interactions between immune and stromal …

Molecular targets of rheumatoid arthritis

H Okamoto, D Hoshi, A Kiire… - … & Allergy-Drug …, 2008 - ingentaconnect.com
Rheumatoid arthritis (RA) is a multifactorial disease characterized by chronic inflammation of
the joints. Both genetic and environmental factors are involved in the pathogenesis of joint …

Targeting pathways and integrated approaches to treat rheumatoid arthritis

SD Dwivedi, K Yadav, A Bhoi, KK Sahu… - Critical Reviews™ in …, 2024 - dl.begellhouse.com
Rheumatoid arthritis (RA) is a chronic symmetrical systemic disorder that not only affects
joints but also other organs such as heart, lungs, kidney, and liver. Approximately there is …

[HTML][HTML] Targeting toll-like receptor (TLR) pathways in inflammatory arthritis: two better than one?

S Santos-Sierra - Biomolecules, 2021 - mdpi.com
Inflammatory arthritis is a cluster of diseases caused by unregulated activity of the immune
system. The lost homeostasis is followed by the immune attack of one's self, what damages …

[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

S Liu, H Ma, H Zhang, C Deng, P Xin - Clinical Immunology, 2021 - Elsevier
Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

Rheumatoid arthritis: biological therapy other than anti-TNF

D Rossi, V Modena, S Sciascia, D Roccatello - International …, 2015 - Elsevier
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is
characterized by synovitis that causes joint damage. The introduction of biologic agents has …

[HTML][HTML] Promising therapeutic targets for treatment of rheumatoid arthritis

J Huang, X Fu, X Chen, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Novel immunotherapeutic avenues for rheumatoid arthritis

L Semerano, E Minichiello, N Bessis… - Trends in Molecular …, 2016 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to
irreversible joint damage, physical handicap, and reduced life expectancy. The past two …