[HTML][HTML] The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies

D Kang, J Lee, C Wu, X Guo, BJ Lee… - … & molecular medicine, 2020 - nature.com
As an essential nutrient and trace element, selenium is required for living organisms and its
beneficial roles in human health have been well recognized. The role of selenium is mainly …

[HTML][HTML] Selenium in bone health: roles in antioxidant protection and cell proliferation

H Zeng, JJ Cao, GF Combs Jr - Nutrients, 2013 - mdpi.com
Selenium (Se) is an essential trace element for humans and animals, and several findings
suggest that dietary Se intake may be necessary for bone health. Such findings may relate to …

[HTML][HTML] Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis

D Kang, J Lee, J Jung, BA Carlson, MJ Chang… - Nature …, 2022 - nature.com
Aging and mechanical overload are prominent risk factors for osteoarthritis (OA), which lead
to an imbalance in redox homeostasis. The resulting state of oxidative stress drives the …

[HTML][HTML] The effects of selenium on bone health: from element to therapeutics

T Yang, SY Lee, KC Park, SH Park, J Chung, S Lee - Molecules, 2022 - mdpi.com
Osteoporosis, characterized by low bone mass and a disruption of bone microarchitecture, is
traditionally treated using drugs or lifestyle modifications. Recently, several preclinical and …

Keshan disease, selenium deficiency, and the selenoproteome

J Loscalzo - New England Journal of Medicine, 2014 - Mass Medical Soc
Keshan Disease, Selenium Deficiency, and the Selenoproteome | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

[HTML][HTML] Understanding the importance of selenium and selenoproteins in muscle function

M Rederstorff, A Krol, A Lescure - Cellular and molecular life sciences, 2006 - Springer
Selenium is an essential trace element. In cattle, selenium deficiency causes dysfunction of
various organs, including skeletal and cardiac muscles. In humans as well, lack of selenium …

[HTML][HTML] Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats

FL Ren, X Guo, RJ Zhang, SJ Wang, H Zuo… - Osteoarthritis and …, 2007 - Elsevier
OBJECTIVE: The purpose of the current study was to investigate the roles of combined
selenium and iodine deficiency in bone development as a possible experimental model of …

[HTML][HTML] Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes

AWM Cheng, TV Stabler, M Bolognesi… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Several lines of evidence show that selenium (Se) has potential protective
effects in osteoarthritis (OA), however the exact mechanism is still unclear. As interleukin-1β …

Selenoproteins and selenium status in bone physiology and pathology

Z Zhang, J Zhang, J Xiao - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Emerging evidence supports the view that selenoproteins are essential for
maintaining bone health. Scope of review The current state of knowledge concerning …

[HTML][HTML] Selenium and selenoproteins in health

F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …