Aim Etoricoxib is a selective inhibitor of COX-2 enzyme. It is proposed as a potent anti-
inflammatory drug intended for the control of irritable bowel syndrome. The current work …

In order to target celecoxib which is a COX2 inhibitor, with potentials in the prevention and
treatment of colitis and colon cancer, it was formulated as microparticles using the …

Context: Celecoxib suffers from low and variable bioavailability following oral administration
of solutions or capsules. Recent studies proved that chemoprevention of colorectal cancer is …

Polymer based nanoparticle formulations have been shown to increase drug bioavailability
and/or reduce drug adverse effects. Nonsteroidal anti-inflammatory drugs (eg celecoxib) …

Eluxadoline is a newly approved orally administered drug used for the treatment of Irritable
Bowel Syndrome with Diarrhea. It is reported as a poorly water-soluble drug due to which its …

Nanoparticles for colon-drug delivery were designed and evaluated to solve many
discrepancy issues as insufficient drug amount at diseased regions, high adverse effects of …

COX-2 inhibitors have demonstrated beneficial effects in colorectal cancer. The purpose of
this study was to prepare and evaluate the colon specific microspheres of COX-2 inhibitors …

The present study involved the in vivo evaluation of orally administered guar gum-based
colon-targeted tablet formulations of celecoxib (colon-targeted tablet-20 or colon-targeted …

The aim of the present study was to prepare valdecoxib, a cyclo-oxygenase-2 enzyme
inhibitor, as a loaded multiparticulate system to achieve site-specific drug delivery to …

Background and purpose: Omeprazole (OMP) is broadly used for the treatment of
gastroesophageal reflux and other acid-related diseases. The current study aimed to …