CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and
tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell …

Immunotherapy-based cancer treatment has revolutionized the era of cancer patients
recuperation and it has brought a strong hope to treatment of some types of cancers …

Metformin, an oral medicine broadly used for the treatment of type 2 diabetes, has been
found to significantly improve tumor incidence and survival in large-scale clinical analysis. In …

Osteosarcoma is one of the most common childhood cancers with high numbers of cancer-
related deaths. Progress in conventional therapies is showing limited improvement. An …

Background Metformin is a commonly used antidiabetic medication which has demonstrated
promise as an anticancer agent alone and in combination with conventional treatment …

Background Despite their revolutionary success in cancer treatment over the last decades,
immunotherapies encounter limitations in certain tumor types and patients. The efficacy of …

Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the
tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites …

Metformin is an oral drug that has been widely used to treat type 2 diabetes mellitus.
Interestingly, accumulated evidence indicate that metformin may reduce the risk of cancer in …

Metformin has been studied for its anticancer effects by regulating T cell functions. However,
the mechanisms through which metformin stimulates the differentiation of memory T cells …

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer
effects; however, the underlying mechanism is poorly understood. Here we show that this …