Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all cancer types with a
constant rise in global incidence. Therefore, better understanding of PDAC biology, in order …

The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen
sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Thyroid cancer is considered to be one of the most common endocrine tumors worldwide.
Cystathionine β‐synthase (CBS) plays a crucial role in the occurrence of several types of …

Background The metabolic reprogramming of amino acids is critical for cancer cell growth
and survival. Notably, intracellular accumulation of cysteine is often observed in various …

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells
induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that …

The cystathionine β-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis
of cystathionine in the trans-sulfuration pathway and is subject to tight regulation because of …

Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal
adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues …

Objective: This study aims to analyze whether Cystathionine β-synthase (CBS) plays roles in
hepatocellular carcinoma (HCC) drug resistance. Methods: MTS assay was used to detect …

T cells could be engineered to overcome the aberrant metabolic milieu of solid tumors and
tip the balance in favor of a long‐lasting clinical response. Here, we explored the therapeutic …