Diabetic polyneuropathy: new strategies to target sensory neurons in dorsal root ganglia
A Miyashita, M Kobayashi, T Yokota… - International Journal of …, 2023 - mdpi.com
Diabetic polyneuropathy (DPN) is the most common type of diabetic neuropathy, rendering a
slowly progressive, symmetrical, and length-dependent dying-back axonopathy with …
slowly progressive, symmetrical, and length-dependent dying-back axonopathy with …
The role of long noncoding RNA MALAT1 in diabetic polyneuropathy and the impact of its silencing in the dorsal root ganglion by a DNA/RNA heteroduplex …
A Miyashita, M Kobayashi, S Ishibashi, T Nagata… - Diabetes, 2022 - Am Diabetes Assoc
Diabetic polyneuropathy (DPN) is the most common complication of diabetes, yet its
pathophysiology has not been established. Accumulating evidence suggests that long …
pathophysiology has not been established. Accumulating evidence suggests that long …
Diabetic polyneuropathy: bridging the translational gap
M Kobayashi, DW Zochodne - Journal of the Peripheral …, 2020 - Wiley Online Library
Clinical trials for diabetic polyneuropathy (DPN) have failed to identify therapeutic impacts
that have arrested or reversed the disorder, despite a long history. This review considers …
that have arrested or reversed the disorder, despite a long history. This review considers …
Novel pathogenic pathways in diabetic neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication affecting more than one
third of diabetes mellitus (DM) patients. Although all cellular components participating in …
third of diabetes mellitus (DM) patients. Although all cellular components participating in …
Transcriptome analysis of dorsal root ganglia's diabetic neuropathy reveals mechanisms involved in pain and regeneration
Peripheral diabetic neuropathy (DN) manifests in nearly 60% of diabetic patients, being pain
its most debilitating symptom. Although electrophysiological and morphological aspects are …
its most debilitating symptom. Although electrophysiological and morphological aspects are …
[HTML][HTML] Neurobiological opportunities in diabetic polyneuropathy
TM Poitras, E Munchrath, DW Zochodne - Neurotherapeutics, 2021 - Elsevier
This review highlights a selection of potential translational directions for the treatment of
diabetic polyneuropathy (DPN) currently irreversible and without approved interventions …
diabetic polyneuropathy (DPN) currently irreversible and without approved interventions …
Non-coding RNA regulators of diabetic polyneuropathy
Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus,
presenting patients and caregivers with a substantial disease burden. Emerging …
presenting patients and caregivers with a substantial disease burden. Emerging …
Understanding the role of hyperglycemia and the molecular mechanism associated with diabetic neuropathy and possible therapeutic strategies
Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …
Evidence for epigenetic regulation of gene expression and function in chronic experimental diabetic neuropathy
C Cheng, M Kobayashi, JA Martinez… - … of Neuropathology & …, 2015 - academic.oup.com
Diabetic polyneuropathy (DPN) is a common but irreversible neurodegenerative
complication of diabetes mellitus. Here we show that features of sensory neuron damage in …
complication of diabetes mellitus. Here we show that features of sensory neuron damage in …
Diabetic neuropathy and the sensory neuron: new aspects of pathogenesis and their treatment implications
M Kobayashi, DW Zochodne - Journal of diabetes investigation, 2018 - Wiley Online Library
Diabetic polyneuropathy (DPN) continues to be generally considered as a “microvascular”
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …
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