Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …

Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …

Mitochondria are eukaryotic organelles known best for their roles in energy production and
metabolism. While often thought of as simply the 'powerhouse of the cell,'these organelles …

Mitochondria represent the major bioenergetic hub coordinating cellular and organismal
homeostasis. The underlying causes of many pathologies tormenting humans converge on …

Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is
associated with various pathologies, including inherited metabolic disorders and age …

Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms …

Multicellular organisms are complex biological systems, composed of specialized tissues
that require coordination of the metabolic and fitness state of each component. In the cells …