Clinical and immunological factors in emphysema progression. Five-year prospective longitudinal exacerbation study of chronic obstructive pulmonary disease (LES …
Rationale: Cross-sectional studies of T-cell responses to self-antigens correlate with
baseline emphysema severity. Objectives: We investigated whether clinical and/or …
baseline emphysema severity. Objectives: We investigated whether clinical and/or …
[HTML][HTML] Autoreactive T cells in human smokers is predictive of clinical outcome
Cross-sectional studies have suggested a role for activation of adaptive immunity in smokers
with emphysema, but the clinical application of these findings has not been explored. Here …
with emphysema, but the clinical application of these findings has not been explored. Here …
Loss of peripheral tolerance in emphysema. Phenotypes, exacerbations, and disease progression
Heterogeneity in the development and progression of cigarette smoke–induced lung
diseases strongly argues for a need to improve the clinical and phenotypic characterization …
diseases strongly argues for a need to improve the clinical and phenotypic characterization …
[HTML][HTML] Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra
JP de-Torres, D Blanco, AB Alcaide, LM Seijo… - PloS one, 2013 - journals.plos.org
Rationale Low-grade inflammation and emphysema have been shown to be associated with
an increased risk of lung cancer. However, the systemic inflammatory response in patients …
an increased risk of lung cancer. However, the systemic inflammatory response in patients …
Mechanisms of autoimmune emphysema
L Taraseviciene-Stewart, N Burns… - Proceedings of the …, 2006 - atsjournals.org
Rationale: Within the lungs of patients with severe emphysema, inflammation continues
despite smoking cessation and is characterized by the presence of T lymphocytes (T cells) …
despite smoking cessation and is characterized by the presence of T lymphocytes (T cells) …
Oligoclonal CD4+ T Cells in the Lungs of Patients with Severe Emphysema
AK Sullivan, PL Simonian, MT Falta… - American journal of …, 2005 - atsjournals.org
Rationale: Within the lungs of patients with severe emphysema, inflammation continues
despite smoking cessation. Foci of T lymphocytes in the small airways of patients with …
despite smoking cessation. Foci of T lymphocytes in the small airways of patients with …
[HTML][HTML] Eosinophil and T cell markers predict functional decline in COPD patients
JM D'Armiento, SM Scharf, MD Roth, JE Connett… - Respiratory …, 2009 - Springer
Background The major marker utilized to monitor COPD patients is forced expiratory volume
in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict …
in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict …
[HTML][HTML] Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
FAA Mohamed Hoesein, P Zanen, PA de Jong… - Respiratory …, 2013 - Springer
Background Little is known about the factors associated with CT-quantified emphysema
progression in heavy smokers. The objective of this study was to investigate the effect of …
progression in heavy smokers. The objective of this study was to investigate the effect of …
Lung mass in smokers
GR Washko, GL Kinney, JC Ross, RSJ Estépar… - Academic radiology, 2017 - Elsevier
Rationale and Objective Emphysema is characterized by airspace dilation, inflammation,
and irregular deposition of elastin and collagen in the interstitium. Computed tomographic …
and irregular deposition of elastin and collagen in the interstitium. Computed tomographic …
[HTML][HTML] Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD
Background Chronic obstructive pulmonary disease (COPD) is characterized by airflow
obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of …
obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of …