Within the past decade, inflammatory and lipid mediators, such as IL-1β, FABP4 and RAGE,
have emerged as important contributors to metabolic dysfunction. As growing experimental …

Over the past decade, a large body of evidence has emerged demonstrating an integration
of metabolic and immune response pathways. It is now clear that obesity and associated …

Obesity reaches up to epidemic proportions globally and increases the risk for a wide
spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension …

Obesity epidemics affect 35.7% of adults and approximately 17% of children in the United
States. Obesity has been associated with several health disorders such as type 2 diabetes …

Obesity and non-alcoholic fatty liver disease (NAFLD) are on the rise world-wide; despite
fervent advocacy for healthier diets and enhanced physical activity, these disorders persist …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Highlights•The inflammasome is involved in chronic inflammation in obese adipose
tissue.•There are reduced numbers of T regulatory cells in adipose tissue in …

The modern rise in obesity and its strong association with insulin resistance and type 2
diabetes have elicited interest in the underlying mechanisms of these pathologies. The …

Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …

Among the rapidly expanding list of factors synthesized and released by white adipose
tissue, the range of cytokines, chemokines and other signaling proteins, collectively termed …