Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current
curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction …

Aims: Reactive oxygen species play a dual role in mediating both cell stress and defense
pathways. Here, we used pharmacological manipulations and siRNA silencing to investigate …

Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial
fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as …

Hearing loss, the most common neurological disorder and the fourth leading cause of years
lived with disability, can have profound effects on quality of life. The impact of this “invisible …

Reactive oxygen species (ROS) production is involved in several apoptotic and necrotic cell
death pathways in auditory tissues. These pathways are the major causes of most types of …

Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that
common mitochondrial gene deletions are closely related to deafness caused by …

Aims: Acquired hearing loss is a worldwide epidemic that affects all ages. It is multifactorial
in etiology with poorly characterized molecular mechanisms. Mitochondria are critical …

Autophagy, a highly conserved cellular mechanism, plays an essential role in the
development and pathology of many central and peripheral nervous system diseases. The …

Clearance of dysfunctional mitochondria via mitophagy is essential for cell survival and
cochlear functions. However, it is not clear which genes are significantly involved in this …

Hearing loss is the most common form of sensory impairment in humans, affecting 5.3%
worldwide population. Although approximately 1 in 500 children are born with impaired …