Biological activity of two anticancer Pt complexes with a cyclohexylglycine ligand against a colon cancer cell line: theoretical and experimental study
Z Hosseini-Hashemi, M Eslami Moghadam… - ACS …, 2022 - ACS Publications
Because of their extraordinary ability to disrupt the natural structure of nucleic acids, metal
complexes could be used in cancer therapy. In this study, cyclohexylglycine (HL) as a ligand …
complexes could be used in cancer therapy. In this study, cyclohexylglycine (HL) as a ligand …
Property evaluation of two anticancer candidate platinum complexes with N-isobutyl glycine ligand against human colon cancer
Z Hosseini˗ Hashemi, M Mirzaei, M Eslami Moghadam - Biometals, 2022 - Springer
Small molecules have potential usage in cancer therapy due to their remarkable potency of
disarranging the natural structure of nucleic acids. In this study, two complexes [Pt (NH3) 2 …
disarranging the natural structure of nucleic acids. In this study, two complexes [Pt (NH3) 2 …
Three anticancer Pt complexes with glycine derivatives: synthesis, bioactivity on MCF-7 cell line, ADME prediction, DFT, MEP, and molecular docking
M Eslami Moghadam, A Jafari… - Journal of the Iranian …, 2021 - Springer
For investigating reduction of side effects of commercial anticancer drugs, such as cisplatin,
three new platinum complexes with glycine derivatives and the formula of [Pt (R-amine) 2 (R …
three new platinum complexes with glycine derivatives and the formula of [Pt (R-amine) 2 (R …
Benzimidazole based Pt (II) complexes with better normal cell viability than cisplatin: synthesis, substitution behavior, cytotoxicity, DNA binding and DFT study
cis-[Pt (ambim) Cl2] 1 (where, ambim= 2-aminomethylbenzimidazole) has been synthesized
and characterized by spectroscopic methods. Reaction kinetics between the hydrolyzed …
and characterized by spectroscopic methods. Reaction kinetics between the hydrolyzed …
Anticancer activity and morphological analysis of Pt (II) complexes: Their DFT approach, docking simulation, and ADME‐Tox profiling
A consistent series of Pt (II) polypyridyl complexes (ie, LDP‐10–25), previously obtained and
characterized by our research group, underwent extensive biological investigations to verify …
characterized by our research group, underwent extensive biological investigations to verify …
Investigating the anticancer properties of the two new platinum complexes with iso-and tert-pentylglycine by the DFT, molecular docking, and ADMET assessment and …
N Ramezani, M Eslami Moghadam… - JBIC Journal of Biological …, 2021 - Springer
In this study, two new anticancer platinum complexes formulated as [Pt (bpy)(L)] NO 3 were
synthesized using the iso and tert-pentylglycine ligands, two structural isomer ligands, to …
synthesized using the iso and tert-pentylglycine ligands, two structural isomer ligands, to …
Tuning anticancer properties and DNA-binding of Pt (ii) complexes via alteration of nitrogen softness/basicity of tridentate ligands
Nine tridentate Schiff base ligands of the type (N^ N^ O) were synthesized from reactions of
primary amines {2-picolylamine (Py), N-phenyl-1, 2-diaminobenzene (PhN), and N-phenyl …
primary amines {2-picolylamine (Py), N-phenyl-1, 2-diaminobenzene (PhN), and N-phenyl …
Development of Anticancer Activity of the Pt(II) Complex with N-Heterocyclic Amine: Its In Vitro Pharmacokinetics with Thiol and Thio-Ethers, DNA and BSA Binding …
A Pan, I Mitra, S Mukherjee, S Ghosh… - ACS Applied Bio …, 2021 - ACS Publications
A dichloro Pt (II) complex with N-heterocyclic amine cis-Pt (PIEAM) Cl2, C-1 (where PIEAM=
1-(2-aminoethyl) piperidine) was synthesized and hydrolyzed to the corresponding [Pt …
1-(2-aminoethyl) piperidine) was synthesized and hydrolyzed to the corresponding [Pt …
Spectroscopic, Anti-Cancer Activity, and DFT Computational Studies of Pt (II) Complexes with 1-Benzyl-3-phenylthiourea and Phosphine/Diamine Ligands
DS Mohamed, SA Al-Jibori, R Behjatmanesh-Ardakani… - Inorganics, 2023 - mdpi.com
The reaction between [PtCl2 (LL)](LL= dppe, dppp, dppb, dppf, Phen and Bipy) or [PtCl2
(PPh3) 2] with 1-benzyl-3-phenylthiourea (H2BPT) in a basic medium (CHCl3/EtOH) created …
(PPh3) 2] with 1-benzyl-3-phenylthiourea (H2BPT) in a basic medium (CHCl3/EtOH) created …
Anticancer property and normal cell toxicity profile of pyrrolidine‐based platinum (II) complexes: Their DNA, BSA interaction, and molecular docking
The bioactivity and cytotoxic property of cis‐[Pt (AEP) Cl2](C‐1);[Pt (AEP)(OH2) 2](NO3) 2 (C‐
2);[Pt (AEP)(GSH)(C‐3)]; and [Pt (AEP)(DL‐meth)] 2+(C‐4)(where AEP= 1‐[2‐Aminoethyl] …
2);[Pt (AEP)(GSH)(C‐3)]; and [Pt (AEP)(DL‐meth)] 2+(C‐4)(where AEP= 1‐[2‐Aminoethyl] …
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