A novel series of quinoxaline derivatives, as Multi-Target-Directed Ligands (MTDLs) for AD
treatment, were designed by lending the core structural elements required for H3R …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and represents the major
cause of dementia worldwide. Currently, there are no available treatments capable to deliver …

In order to develop multitarget-directed ligands as potential treatments for Alzheimer's
disease, twenty-eight new tacrine-hydroxamate derivatives were designed, synthesized, and …

A series of multitarget ligands was designed by introducing several structurally diverse
aminoacetamide groups at position 6 of the deoxyvasicinone group, with the aim of …

The most successful therapeutic strategy in the treatment of Alzheimer's disease (AD) is
directed toward increasing levels of the neurotransmitter acetylcholine (ACh) by inhibition of …

Accumulation of evidences suggested that excessive amounts of AChE and BuChE in the
brain of AD patients at the different stage of AD, which could hydrolyze ACh and accelerated …

Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …

In this paper, the preparation of a new class of multi-target-directed ligands (MTDLs) based
on a 7-amino-1, 4-dihydro-2H-isoquilin-3-one, whose lead (compound I) showed promising …

To develop multitarget-directed ligands (MTDLs) as potential treatments for Alzheimer's
disease (AD) and to shed light on the effect of the chromene group in designing these …

A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety were synthesized,
and evaluated as multifunctional agents against Alzheimer's disease (AD). Most of the …