Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to
study mechanisms of disease progression and therapy response, yet little is known about …

Radiobiology research in rectal cancer has been limited to cell lines, patient-derived
organoids (PDOs), or xenografts. Here, we describe a protocol which recapitulates more …

A lack of clinically relevant experimental models of human prostate cancer hampers
evaluation of potential therapeutic agents. Currently, androgen deprivation therapy is the …

To study the multifaceted biology of prostate cancer, pre-clinical in vivo models offer a range
of options to uncover critical biological information about this disease. The human orthotopic …

Genetically engineered mouse models (GEMMs) are valuable research tools that have
transformed our understanding of cancer. The first GEMMs generated in the 1980s and …

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …

Purpose To optimize the combination of ionizing radiation and cellular immunotherapy using
a preclinical autochthonous model of prostate cancer. Methods and Materials Transgenic …

Background In vitro models of prostate cancer (PCa) are not always reliable to evaluate
anticancer treatment efficacy. This limitation may be overcome by using viable tumor slice …

Orthotopic tumor modeling is a valuable tool for pre-clinical prostate cancer research, as it
has multiple advantages over both subcutaneous and transgenic genetically engineered …

Genetically engineered mouse models (GEMM s) have contributed significantly to the field of
cancer research. In contrast to cancer cell inoculation models, GEMM s develop de novo …