New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis
JT Brenna, KSD Kothapalli - Current Opinion in Clinical Nutrition & …, 2022 - journals.lww.com
The mixture of fatty acids available to FADS2 in any tissue defines the product mixture
available for further synthesis of membrane lipids and signaling molecules and may be …
available for further synthesis of membrane lipids and signaling molecules and may be …
A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids
WJ Park, KSD Kothapalli, HT Reardon… - Journal of lipid …, 2012 - ASBMB
The fatty acid desaturase (FADS) genes code for the rate-limiting enzymes required for the
biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA). Here we report discovery …
biosynthesis of long-chain polyunsaturated fatty acids (LCPUFA). Here we report discovery …
Apocryphal FADS2 activity promotes fatty acid diversification in cancer
Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result
in products with well-defined chain lengths, degree (s), and positions of unsaturation. Deep …
in products with well-defined chain lengths, degree (s), and positions of unsaturation. Deep …
The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20: 1 to 7, 11-20: 2
Introduction In mammals, FADS2 catalyzes “front-end” Δ4-, Δ6-, and Δ8-desaturation of fatty
acyl chains, whereas FADS1 has Δ5-desaturase activity. Eighteen and 20-carbon …
acyl chains, whereas FADS1 has Δ5-desaturase activity. Eighteen and 20-carbon …
Fads3 modulates docosahexaenoic acid in liver and brain
Abstract Fatty acid desaturase 3 (FADS3) is the third member of the FADS gene cluster.
FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) …
FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) …
Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts
The fatty acid desaturase (FADS) gene family at 11q12-13.1 includes FADS1 and FADS2,
both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated …
both known to mediate biosynthesis of omega-3 and omega-6 long-chain polyunsaturated …
A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency
Fatty acid delta-6-desaturase (FADS2) is the rate-limiting enzyme in mammalian synthesis of
long-chain polyunsaturated fatty acids. We investigated the molecular mechanism of FADS2 …
long-chain polyunsaturated fatty acids. We investigated the molecular mechanism of FADS2 …
Alternative splicing generates a novel FADS2 alternative transcript in baboons
WJ Park, HT Reardon, C Tyburczy… - Molecular biology …, 2010 - Springer
The mammalian fatty acid desaturase 2 (FADS2) gene codes for catalytic activity considered
to be the rate limited step in long chain polyunsaturated fatty acid (LCPUFA) synthesis …
to be the rate limited step in long chain polyunsaturated fatty acid (LCPUFA) synthesis …
FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer
KSD Kothapalli, HG Park, NSL Kothapalli… - Progress in Lipid …, 2023 - Elsevier
Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several
cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as …
cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as …
FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids
LM Reynolds, R Dutta, MC Seeds, KN Lake… - Scientific reports, 2020 - nature.com
Humans have undergone intense evolutionary selection to optimize their capacity to
generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA) …
generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA) …