From static to dynamic: a review on the role of mucus heterogeneity in particle and microbial transport
DD Pednekar, MA Liguori, CNH Marques… - ACS Biomaterials …, 2022 - ACS Publications
Mucus layers (McLs) are on the front line of the human defense system that protect us from
foreign abiotic/biotic particles (eg, airborne virus SARS-CoV-2) and lubricates our organs …
foreign abiotic/biotic particles (eg, airborne virus SARS-CoV-2) and lubricates our organs …
[HTML][HTML] Empirical and theoretical analysis of particle diffusion in mucus
A Cobarrubia, J Tall, A Crispin-Smith, A Luque - Frontiers in Physics, 2021 - frontiersin.org
Mucus is a complex fluid that coats multiple organs in animals. Various physicochemical
prop-erties can alter the diffusion of microscopic particles in mucus, impacting drug delivery …
prop-erties can alter the diffusion of microscopic particles in mucus, impacting drug delivery …
Mimicking the gastrointestinal mucus barrier: laboratory-based approaches to facilitate an enhanced understanding of mucus permeation
The gastrointestinal mucus layer plays a significant role in maintaining gut homeostasis and
health, offering protective capacities against the absorption of harmful pathogens as well as …
health, offering protective capacities against the absorption of harmful pathogens as well as …
Direct measurement of macromolecule-coated colloid–mucus interactions
JC Swavola, TD Edwards, MA Bevan - Langmuir, 2015 - ACS Publications
We report measurements of macromolecule-coated colloids interacting with mucus to
understand colloidal particle diffusion near mucus-coated surfaces. Total internal reflection …
understand colloidal particle diffusion near mucus-coated surfaces. Total internal reflection …
Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells
J Campos-Gomez, C Fernandez Petty… - … of Physiology-Lung …, 2023 - journals.physiology.org
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is
devastatingly impacting human health. A prominent component of COVID-19 is the infection …
devastatingly impacting human health. A prominent component of COVID-19 is the infection …
[HTML][HTML] A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease
In human airways diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary
disease (COPD), host defense is compromised and airways inflammation and infection often …
disease (COPD), host defense is compromised and airways inflammation and infection often …
The yielding behaviour of human mucus
D Kavishvar, A Ramachandran - Advances in Colloid and Interface Science, 2023 - Elsevier
Mucus is a viscoelastic material with non-linear rheological properties such as yield stress of
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …
[HTML][HTML] Cilia-driven particle and fluid transport over mucus-free mice tracheae
To date, there is only a fragmentary understanding of the fundamental mechanisms of
airway mucociliary transport. Application of the latest measurement techniques can aid in …
airway mucociliary transport. Application of the latest measurement techniques can aid in …
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties
BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …
Modeling mucus physiology and pathophysiology in human organs-on-chips
Z Izadifar, A Sontheimer-Phelps, BA Lubamba… - Advanced Drug Delivery …, 2022 - Elsevier
The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …
relationships with commensal microbiome while protecting against potentially injurious …