Integration between tendon/ligament and bone occurs through a specialized tissue interface
called enthesis. The complex and heterogeneous structure of the enthesis is essential to …

Tendon-to-bone interface (enthesis) exhibits a complex multiscale architectural and
compositional organization maintained by a heterogeneous cellular environment …

Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex
structure, composition, cell population and mechanics of the interface. With rapid advances …

Repairing injured tendon or ligament attachments to bones (enthesis) remains costly and
challenging. Despite superb surgical management, the disorganized enthesis newly formed …

The enthesis, or interface between bone and soft tissues such as ligament and tendon, is
prone to injury and often does not heal, even post surgical intervention. Interface tissue …

Injuries to connective tissues are painful and disabling and result in costly medical
expenses. These injuries often require reattachment of an unmineralized connective tissue …

Connective tissues such as tendons or ligaments attach to bone across a multitissue
interface with spatial gradients in composition, structure, and mechanical properties. These …

The musculoskeletal system works at a very advanced level of synchrony, where all the
physiological movements of the body are systematically performed through well-organized …

A major focus in the field of orthopedic tissue engineering is the development of tissue
engineered bone and soft tissue grafts with biomimetic functionality to allow for their …

Tendon and ligaments have poor healing capacity and when injured often require surgical
intervention. Tissue replacement via autografts and allografts are non-ideal strategies that …