In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short
overview of CPP history and discuss several aspects of CPP classification. Next section is …

Cell-penetrating peptides (CPPs) are short peptides of less than 30 amino acids that are
able to penetrate cell membranes and translocate different cargoes into cells. The only …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability has made of delivery a keystone in therapeutic …

During the three decades of cell-penetrating peptides era the superfamily of CPPs has
rapidly expanded, and the quest for new sequences continues. CPPs have been well …

More than a decade ago, it was discovered that cationic peptides could traverse the cellular
plasma membrane without specific transporter proteins or membrane damage …

In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

Cell-penetrating peptides (CPPs) share the property of cellular internalization. The question
of how these peptides reach the cytoplasm of cells is still widely debated. Herein, we have …

As our knowledge increases about the diversity in uptake mechanisms displayed by cell-
penetrating peptides (CPP), the concept of CPP uptake kinetics becomes increasingly …

The main problem of therapeutic efficiency lies in the crossing of cellular membranes.
Therefore, significant effort is being made to develop agents which can cross these barriers …

The classical view on how peptides enter cells has been changed due to the development in
the research field of cell-penetrating peptides (CPPs). During the last 15 years, more than …