Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …

Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

Increased proteolytic activity is a hallmark of several pathological processes, including
neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine …

Proper function of lysosomes is particularly important in neurons, as they cannot dilute
accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal …

Background Lysosomal dysfunction has been implicated in a number of neurodegenerative
diseases such as Parkinson's disease (PD). Various molecular, clinical and genetic studies …

Cathepsins B and L are lysosomal cysteine proteases which have been implicated in a
variety of pathological processes such as cancer, tumor angiogenesis, and …

Lysosomal proteinases (cathepsins) and their endogenous inhibitors (cystatins) have been
found to be closely associated with senile plaques, cerebrovascular amyloid deposits, and …

The identification of cathepsins in amyloid-β plaques revealed broad dysfunction of the
lysosomal system in Alzheimer's disease (AD). Coinciding with the discovery that proteolysis …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various
substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid …