[HTML][HTML] The impact of ZIP8 disease-associated variants G38R, C113S, G204C, and S335T on selenium and cadmium accumulations: The first characterization

ZL Liang, HW Tan, JY Wu, XL Chen, XY Wang… - International Journal of …, 2021 - mdpi.com
The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the
essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium …

[HTML][HTML] Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction

HW Tan, YM Xu, ZL Liang, NL Cai, YY Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Human transmembrane protein metal cation symporter ZIP8 (SLC39A8) is a member of the
solute carrier gene family responsible for intracellular transportation of essential …

Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)

ZS Zang, YM Xu, ATY Lau - Toxicology research, 2016 - academic.oup.com
Abstract Zinc ion (Zn2+) is essential for life; its deficiency in the human body could cause
stunted growth, anemia and susceptibility to infection. The Zn transporter ZIP8 (also known …

Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation

L Liu, X Geng, Y Cai, B Copple… - American Journal …, 2018 - journals.physiology.org
Zrt/Irt-like protein 8 (ZIP8)(encoded by Slc39a8) is a multifunctional membrane transporter
that influxes essential metal cations Zn2+, Mn2+, Fe2+, and nonmetal inorganic selenite …

[HTML][HTML] ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading

CY Wang, S Jenkitkasemwong, S Duarte… - Journal of Biological …, 2012 - ASBMB
ZIP8 (SLC39A8) belongs to the ZIP family of metal-ion transporters. Among the ZIP proteins,
ZIP8 is most closely related to ZIP14, which can transport iron, zinc, manganese, and …

[HTML][HTML] Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression

J Jin, Z Li, J Liu, Y Wu, X Gao, Y He - Oncology reports, 2015 - spandidos-publications.com
ZIP5 is a central player in mammalian zinc metabolism. Studies suggest that ZIP5 is
differentially expressed during esophageal tumorigenesis, yet the role of ZIP5 in esophageal …

Reduced Mn uptake of pleiotropic ZIP8 SNP is caused by its loss of Mn-responsive accumulation on the cell-surface

Y Nishito, H Fujishiro, S Nagamatsu… - Bioscience …, 2024 - academic.oup.com
Abstract Zrt/Irt-like protein 8 (ZIP8), which is a zinc transporter, plays a pivotal role as a
manganese transporter. Recent studies have shown that a ZIP8 SNP (rs13107325 C→ T …

Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2

X Geng, L Liu, KJ Tsai, Z Liu - Toxicology and applied pharmacology, 2019 - Elsevier
ZIP8 is a membrane transporter that facilitates the uptake of divalent metals (eg, Zn, Mn, Fe,
Cd) and the mineral selenite in anionic form. ZIP8 functionality has been recently reported to …

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

S Jenkitkasemwong, CY Wang, B Mackenzie… - Biometals, 2012 - Springer
Zinc, iron, and manganese are essential trace elements that serve as catalytic or structural
components of larger molecules that are indispensable for life. The three metal ions possess …

Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese-and cadmium-transporting activity

H Fujishiro, S Miyamoto, D Sumi, T Kambe… - Biochemical and …, 2022 - Elsevier
Abstract Zinc (Zn) transporter ZIP8, encoded by SLC39A8, is a unique transporter that can
transport divalent manganese (Mn) and cadmium (Cd) in addition to Zn. Recently …