The present review aimed to establish an understanding of the pathophysiology of
leptomeningeal disease as it relates to late-stage development among different cancer …

Leptomeningeal metastases (LM) are increasingly recognized as a devastating complication
of solid tumors. Improved treatment of primary malignancy and advances in diagnostic …

Simple Summary Leptomeningeal metastases occur when cancer cells reach the fluid-filled
space that surrounds the brain and spinal cord. This type of brain lesion is most prevalent in …

Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a
poor prognosis and limited treatment options. Diagnosis is often challenging, with …

Leptomeningeal metastasis (LMD) refers to the dissemination of cancer to the arachnoid
mater, cerebrospinal fluid (CSF), and pia mater, which occurs in approximately 5% to 8% of …

Leptomeningeal metastasis (LM), also known as leptomeningeal carcinomatosis (LC), is a
devastating complication of metastatic cancer that occurs when neoplastic cells invade the …

Leptomeningeal metastasis is a devastating complication of the central nervous system in
patients with late-stage solid or hematological cancers. Leptomeningeal metastasis results …

Leptomeningeal metastases (LMM) consist of diffuse involvement of the leptomeninges by
infiltrating cancer cells. In solid tumors, the most frequent primary sites are lung and breast …

Leptomeningeal metastasis (LM) results from dissemination of cancer cells to both the
leptomeninges (pia and arachnoid) and cerebrospinal fluid (CSF) compartment. Breast …

Leptomeningeal metastasis (LM) is a severe complication in the natural history of
malignancies that occurs in 4–15% of patients (pts) with solid tumors. Clinical presentation …