Gene-edited pigs: a translational model for human food allergy against alpha-Gal and anaphylaxis

Y Wang, M Hils, A Fischer, F Wölbing… - Frontiers in …, 2024 - frontiersin.org
The prevalence of food allergy is rising and is estimated to approach 10%. Red meat allergy
is the first known food allergy elicited by immunoglobulin E (IgE) antibodies recognizing a …

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4

M Hils, N Hoffard, C Iuliano, L Kreft… - Journal of Allergy and …, 2024 - Elsevier
Background Alpha-gal (Galα1-3Galβ1-4GlcNAc) is a carbohydrate with the potential to elicit
fatal allergic reactions to mammalian meat and drugs of mammalian origin. This type of …

Development of a novel murine model of alpha-gal meat allergy

SP Commins, S Karim - Journal of Allergy and Clinical Immunology, 2017 - jacionline.org
Methods Wild type (WT) mice were given either Amblyomma americanum (Aa) tick salivary
gland extract intradermally (50μg) or saline on days 0, 7 and 21. IgE was assessed on day …

[HTML][HTML] Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

SR Sharma, SK Choudhary, J Vorobiov… - Frontiers in …, 2024 - frontiersin.org
Introduction Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE
antibodies targeting galactose-α-1, 3-galactose (α-gal), a carbohydrate found in red meat …

On the cause and consequences of IgE to galactose-α-1, 3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on …

TAE Platts-Mills, SP Commins, T Biedermann… - Journal of Allergy and …, 2020 - Elsevier
The mammalian meat allergy known as the “α-Gal syndrome” relates to IgE specific for
galactose-α-1, 3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of …

Role and mechanism of galactose-alpha-1, 3-galactose in the elicitation of delayed anaphylactic reactions to red meat

C Hilger, J Fischer, F Wölbing… - Current allergy and asthma …, 2019 - Springer
Abstract Purpose of Review The alpha-Gal (α-Gal) syndrome is characterized by the
presence of IgE antibodies directed at the carbohydrate galactose-alpha-1, 3-galactose (α …

Tick salivary gland extract induces alpha‐gal syndrome in alpha‐gal deficient mice

SK Choudhary, S Karim, OI Iweala… - Immunity …, 2021 - Wiley Online Library
Introduction Alpha‐gal syndrome (AGS) is characterized by delayed hypersensitivity to non‐
primate mammalian meat in people having specific immunoglobulin E (sIgE) to the …

Where's the beef? Understanding allergic responses to red meat in alpha-gal syndrome

AS Carson, A Gardner, OI Iweala - The Journal of Immunology, 2022 - journals.aai.org
Alpha-gal syndrome (AGS) describes a collection of symptoms associated with IgE-
mediated hypersensitivity responses to the glycan galactose-alpha-1, 3-galactose (alpha …

Environmental and molecular drivers of the α-Gal syndrome

A Cabezas-Cruz, A Hodžić… - Frontiers in …, 2019 - frontiersin.org
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab)
response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in …

The red meat allergy syndrome in Sweden

D Apostolovic, TAT Tran, M Starkhammar… - Allergo journal …, 2016 - Springer
In the last decade, a novel type of food allergy presenting with severe allergic reactions
several hours after consumption of red meat has been recognized. The allergic responses …