Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

Clinical efforts to repair damaged articular cartilage (AC) currently face major obstacles due
to limited intrinsic repair capacity of the tissue and unsuccessful biological interventions …

Osteoarthritis (OA) is an age related joint disease associated with degeneration and loss of
articular cartilage. Consequently, OA patients suffer from chronic joint pain and disability …

Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal
spontaneously. Defects that penetrate to the subchondral bone elicit an intrinsic repair …

Defects of load-bearing connective tissues such as articular cartilage, often result from
trauma, degenerative or age-related disease. Osteoarthritis (OA) presents a major clinical …

Treatment for articular cartilage damage is quite challenging as it shows limited repair and
regeneration following injury. Non-operative and classical surgical techniques are inefficient …

Osteoarthritis, the most prevalent form of joint disease, afflicts 9% of the US population over
the age of 30 and costs the economy nearly $100 billion annually in healthcare and …

Articular cartilage (AC) is a highly organized connective tissue lining, covering the ends of
bones within articulating joints. Its highly ordered structure is essential for stable motion and …

Focal chondral or osteochondral lesions can be painful and disabling because they have
insufficient intrinsic repair potential, and constitute one of the major extrinsic risk factors for …

Osteoarthritis (OA) is a debilitating, degenerative joint disease characterized by progressive
destruction of articular cartilage. Given the poor repair capacity of articular cartilage and the …