[HTML][HTML] Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation

CJ Hill, MM Phelan, PJ Dutton, P Busuulwa… - Scientific Reports, 2024 - nature.com
A significant number of pregnancies are lost in the first trimester and 1–2% are ectopic
pregnancies (EPs). Early pregnancy loss in general can cause significant morbidity with …

[HTML][HTML] Screening for preterm birth: potential for a metabolomics biomarker panel

EC Considine, AS Khashan, LC Kenny - Metabolites, 2019 - mdpi.com
The aim of this preliminary study was to investigate the potential of maternal serum to
provide metabolomic biomarker candidates for the prediction of spontaneous preterm birth …

Utility of metabolic profiling of serum in the diagnosis of pregnancy complications

KL Powell, A Carrozzi, AS Stephens, V Tasevski… - Placenta, 2018 - Elsevier
Introduction Currently there are no clinical screening tests available to identify pregnancies
at risk of developing preeclampsia (PET) and/or intrauterine growth restriction (IUGR), both …

[HTML][HTML] Trace biomarkers associated with spontaneous preterm birth from the maternal serum metabolome of asymptomatic nulliparous women–parallel case-control …

RT Souza, EJ McKenzie, B Jones, JV de Seymour… - Scientific reports, 2019 - nature.com
Prediction of spontaneous preterm birth (sPTB) in asymptomatic women remains a great
challenge; accurate and reproducible screening tools are still not available in clinical …

Metabolomics Identifies a Panel of Diagnostic Biomarkers for Early Human Embryonic Development Arrest

Y Liu, X Fan, H Pang, S Liu, B Wang… - Journal of Proteome …, 2023 - ACS Publications
Early embryonic development arrest (EEDA) is a unique form of early spontaneous abortion
in pregnant women, which is previously suggested to be associated with metabolic …

[HTML][HTML] Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: A case–control discovery phase study

EW Harville, YY Li, K Pan, S McRitchie… - Scientific Reports, 2021 - nature.com
Understanding of causal biology and predictive biomarkers are lacking for hypertensive
disorders of pregnancy (HDP) and preterm birth (PTB). First-trimester serum specimens from …

Metabolomic identification of novel diagnostic biomarkers in ectopic pregnancy

O Turkoglu, A Citil, C Katar, I Mert, P Kumar, A Yilmaz… - Metabolomics, 2019 - Springer
Introduction Ectopic pregnancy (EP) is a potentially life-threatening condition and early
diagnosis still remains a challenge, causing a delay in management leading to tubal rupture …

[HTML][HTML] Predictive analytical model for ectopic pregnancy diagnosis: Statistics vs. machine learning

P Rueangket, K Rittiluechai, A Prayote - Frontiers in Medicine, 2022 - frontiersin.org
Objective Ectopic pregnancy (EP) is well known for its critical maternal outcome. Early
detection could make the difference between life and death in pregnancy. Our aim was to …

[HTML][HTML] A non-targeted LC–MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

T Jääskeläinen, O Kärkkäinen, J Jokkala, A Klåvus… - Metabolomics, 2021 - Springer
Introduction Maternal metabolism changes substantially during pregnancy. However, few
studies have used metabolomics technologies to characterize changes across gestation …

[HTML][HTML] Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy

LA Beer, X Yin, J Ding, S Senapati, MD Sammel… - Clinical Proteomics, 2023 - Springer
Background Differentiating between a normal intrauterine pregnancy (IUP) and abnormal
conditions including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical …